PLANS to build a $100 million cancer centre in Sydney's ritzy inner-eastern suburb of Darlinghust are in jeopardy, after a group of local residents and Lord Mayor Clover Moore, said the development would "cannibalise" their suburb.

Mr Moore said the proposed 11-storey building - which was launched by singer Delta Goodrem last October - risks blocking sunlight to nearby homes, and will also cause traffic chaos.